In the film, he is sent by Noah Vosen to Tangier to eliminate Neil Daniels. Jason Bourne, with the aid of Nicky Parsons, attempts to interfere and as such become his next targets since Nicky breaks CIA protocol. Sadly, Daniels is killed in the planned car bombing by Desh, also injuring Bourne in the process. Soon after that, Desh follows Parsons through the Morocco market with intention of killing her. However, Bourne is able to locate and engage him in hand-to-hand combat, ultimately suffocating him with a towel. Bourne uses Desh's cellphone to deliberately make Vosen think that he and Nicky have been killed. He is also referred to in the special edition dvd commentary as a young Bourne, and it is hinted that he has gone through the same training as Bourne.
Desh uses a supressed H&K USP .45 compact as well as several home made I.E.D.s.